101 Medical Autopsy Cases Adult and Pediatric

Nandita Bharadwaj Kakkar

In this book, the author has given a comprehensive description of 101 Medical Autopsy Cases (48 Adults and 53 Pediatrics) with their complete clinical and pathological details. Medical Autopsy is the strongest teaching tool in medicine, but unfortunately its practice has declined worldwide. In Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, the Department of Histopathology performs 500-600 Medical Autopsies per year. These 101 cases have been presented in the routine Clinico-Pathologic Correlation Conferences (CPCs)/Pediatric Rounds. This book is a collection of the authors' 27 years of service in this institute. Each case is unique and has been discussed in a simple, practical, straightforward, but comprehensive manner under the following headings-Highlights, Clinical Details, Complete Histopathological Findings with a Gallery (over 3000) of Gross and Microscopic Photographs, Final Autopsy Diagnosis, Review of Literature, Discussion of Index Case with its Peculiarities, Take Home Message and Suggested Reading. The author says that this was a 'CALL BEYOND HER DUTY; to compile this immensely valuable learning material, which probably would have got deleted from her computer, once she would retire. For knowledge to live, its propagation is a must.

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CASE 1 Mantle Cell Lymphoma, Presenting with Florid Cutaneous Lesions, with Common Variant Morphology in the Nodal/Extranodal Sites and Blastoid Morphology in the Peripheral Blood: PM 25983
CASE 2 Primary Myelofibrosis, Cellular Phase with Formation of Sclerosing Extramedullary Hematopoietic Tumors: PM 27873
CASE 3 Primary Myelofibrosis, Cellular Phase with Extensive Extramedullary Hematopoiesis and Transformation into Acute Leukemia: PM 23618
CASE 4 Hepatosplenic T-cell Lymphoma: PM 23096
CASE 5 Acute Promyelocytic Leukemia with Early Death due to Disseminated Intravascular Coagulation and Right Temporal Lobe Hemorrhage: PM 26880
CASE 6 Acute Promyelocytic Leukemia with Differentiation Syndrome: PM 17959
CASE 7 Chronic Lymphatic Leukemia, Post-Bone Marrow Transplantation with Recurrence, Massive Lymphadenopathy and Hemophagocytosis: PM 21710
CASE 8 Symptomatic Plasma Cell Myeloma with Primary Systemic Amyloidosis Showing a Predominant Involvement of the Heart and Gastrointestinal Tract: PM 19667
CASE 9 Microscopic/Occult Testicular Seminoma with Germ Cell Neoplasia in situ and Widespread Nonseminomatous Metastasis in a Young Male: PM 14170
CASE 10 Malignant Teratoma, Primary Pulmonary, Containing Yolk Sac Tumor, Associated with Hematologic Neoplasia: PM 13633
CASE 11 Young Male with Metastasis: Do not Waste Time—Look for the Primary in the Testes: PM 19388
CASE 12 Occult, Peripheral, Mucin-secreting Adenocarcinoma of Lung with Florid Meningeal Carcinomatosis along with Thrombotic Microangiopathy and Disseminated Intravascular Coagulation, Leading to Bilateral Renal Infarction: PM 26226
CASE 13 Young Male with Occult, Diffuse Type, Mucin-secreting Adenocarcinoma of the Stomach with Extensive Lymphangitic Carcinomatosis, Presenting with Deep Vein Thrombosis and Pulmonary Embolism: PM 21829
CASE 14 Amebic Ileocolitis, Perforation and Liver Abscess: PM 18836
CASE 15 Cerebral Toxoplasmosis in a Human Immunodeficiency Virus Positive Patient: PM 19210
CASE 16 Pulmonary Hyalinizing Granuloma with Recent Onset Cryptococcal Meningoencephalitis in an Immunocompetent Male: PM 21122
CASE 17 Leptospirosis with Multiorgan Involvement: PM 22793
CASE 18 Silicotuberculosis: PM 26075
CASE 19 Rabies Meningoencephalitis, Post-Pet Dog Bite: PM 27786
CASE 20 Extrahepatic Portal Venous Obstruction due to Cavernomatous Transformation of Portal Vein and Portal Cavernoma Cholangiopathy: PM 22260
CASE 21 Chronic Budd-Chiari Syndrome with Mesoatrial Shunt, Venocentric Cirrhosis, Hepatocellular Carcinoma Infiltrating into the Hepatic Duct Causing Obstruction and Hemobilia: PM 27800
CASE 22 Acute on Chronic Pancreatitis Leading to Portal Vein Pyemia, with Multiple Liver Abscesses and Life-threatening Sepsis Shock: PM 25975
CASE 23 Lipomatous Pseudohypertrophy of the Pancreas with Polyglandular Autoimmune Syndrome Type II and Inflammatory Myopathy: PM 22590
CASE 24 Young Male with Early Onset Micronodular Cirrhosis due to Synergistic Hepatotoxic effect of Alcohol and Hepatitis C Virus Infection along with Cryoglobulinemic Vasculitis: PM 27791
CASE 25 Diffuse Hepatocellular Carcinoma Arising in a Setting of Mixed Nodular Cirrhosis, Hepatitis C Virus and Alcohol Related: PM 26695
CASE 26 Acute Liver Failure and Encephalopathy in a Case of Dengue Shock Syndrome: PM 25035
CASE 27 Postpartum, Hyperacute, Fulminant Hepatic Failure due to Hepatitis E Virus: PM 26595
CASE 28 Sporadic, Hepatitis E-related Massive Hepatic Necrosis in a Young Female: PM 26254
CASE 29 A Classical Case of Wilson's Disease with Hepatic and Neuropsychiatric Manifestations: PM 26195
CASE 30 Silent Healed Myocardial Infarction and its Complications—Infarct Expansion, Mural Thrombosis, Aneurysm Formation, Extensive Arterial Embolization, Deep Vein Thrombosis and Subsequent Fatal Venous Thromboembolism: PM 21817
CASE 31 Coexistence of Acute-on-Chronic Rheumatic Heart Disease and Acute Poststreptococcal Glomerulonephritis: PM 21119
CASE 32 A Classical Case of Marfan Syndrome with Aortic Root Dilatation, Aneurysm of the Ascending Aorta and Acute Aortic Dissection: PM 22554
CASE 33 Adult Tetralogy of Fallot with Tricuspid Valve Infective Endocarditis and Thromboembolic Botryomycotic Cerebral Abscess: PM 26941
CASE 34 Cocaine-induced Vasculopathy Leading to Cardiomyopathy, Renal Infarcts, Gangrene of Digits with Autoamputation: PM 23445
CASE 35 Aftermath of Hypertension in a Middle-aged Male—Intraparenchymal Brain Hemorrhage, Pontine and Thalamic: PM 26485
CASE 36 Renal Limited Microscopic Polyangiitis: PM 13127
CASE 37 Microscopic Polyangiitis, ANCA Negative, with Florid Glomerulitis and Granulomatous Glomerulonephritis: PM 15649
CASE 38 Microscopic Polyangiitis in a Child: PM 16450
CASE 39 Microscopic Polyangiitis, ANCA Negative, Clinically Mimicking Granulomatosis with Polyangiitis (Wegener's Granulomatosis) and Presenting with a Breast Mass: PM 18473
CASE 40 Microscopic Polyangiitis—Chronic Phase: PM 18987
CASE 41 Microscopic Polyangiitis with Acute Vasculitis of Small, Medium and Large-sized Arteries: PM 20415
CASE 42 p-ANCA Positive Classic Polyarteritis Nodosa: PM 24277
CASE 43 Takayasu's Aortoarteritis, Pulmonary Hypertension, and Pulmonary Capillary Hemangiomatosis: PM 14993
CASE 44 Takayasu Aortoarteritis, Presenting with Pulmonary Arterial Hypertension Secondary to Extensive Involvement of Right Pulmonary Artery: PM 25988
CASE 45 Granulomatosis with Polyangiitis (Wegener's Granulomatosis) with Left Foot Gangrene and Right Hemiplegia: PM 14106
CASE 46 Granulomatosis with Polyangiitis—Wegener's Granulomatosis, Presenting as an Anterior Mediastinal Mass: PM 18613
CASE 47 Granulomatosis with Polyangiitis, i.e. Wegener's with Multiple Pulmonary Nodules and Total Splenic Necrosis: PM 21594
CASE 48 c-ANCA Positive, Nonreactive, Disseminated Tuberculosis with Pulmonary and Mesenteric Vasculitis: PM 14513
CASE 49 Isolated Bilateral Renal Mucormycosis with Contiguous Spread to the Adrenals, Mesentery, Pancreas and Colon in an Apparently Immunocompetent Adult: PM 27250
CASE 50 Primary Bilateral Renal Mucormycosis in an Apparently Immunocompetent Child: PM 22863
CASE 51 Primary/Familial Hemophagocytic Lymphohistiocytosis with Extensive Involvement of the Brain: PM 20788
CASE 52 Langerhans Cell Histiocytosis Presenting as an Anterior Mediastinal Mass: PM 21476
CASE 53 Macrophage Activation Syndrome—A Fatal Complication of Systemic Onset Juvenile Idiopathic Arthritis: PM 26202
CASE 54 Epstein-Barr Virus-associated Secondary Hemophagocytic Lymphohistiocytosis—A Rare Complication: PM 21703
CASE 55 Disseminated Bacillus Calmette-Guérin Infection in a Case of Severe Combined Immunodeficiency: PM 22931
CASE 56 Chronic Granulomatous Disease of Childhood: PM 24170
CASE 57 Disseminated Nonreactive Tuberculosis, PCR-Proven Dual Positivity for Mycobacterium Tuberculosis and Abscessus ? Mendelian Susceptibility to Mycobacterial Disease: PM 25174
CASE 58 Congenital Nephrotic Syndrome of the Finnish Type: PM 23777
CASE 59 Infantile Nephrotic Syndrome—Diffuse Mesangial Sclerosis in a 10-Month-Old Male Child: PM 26462
CASE 60 Disseminated Congenital Cytomegalovirus Infection with Islet Cell Hyperplasia as the Cause of Persistent Hypoglycemia in a Neonate: PM 23822
CASE 61 Congenital Tuberculosis: An Underdiagnosed Entity: PM 24753
CASE 62 Disseminated Cryptococcomas Mimicking Disseminated Malignancy, with Hepatic Dysfunction as the Initial Manifestation, in an Immunocompetent Child: PM 25744
CASE 63 Catastrophic Posterior Circulation Tubercular Arteritis with Infarcts and Cortical Venous Thrombosis—A Rare Co-existence: PM 26344
CASE 64 Child with Disseminated Miliary Tuberculosis, Tubercular Meningitis with Extensive Arteritis, Infarction and Ischemic Hepatitis: PM 25901
CASE 65 Disseminated Cryptococcal Infection in an HIV-positive Child: PM 23563
CASE 66 Transposition of Great Arteries: PM 24027
CASE 67 Child with Acute Lymphoblastic Leukemia on Induction Therapy with Febrile Neutropenia and Disseminated Aspergillus Infection: PM 25927
CASE 68 Myeloid Sarcoma of Lacrimal Sac as the First Manifestation of AML-M1 with Acute Diffuse Colorectal Neutropenic Colitis in a Child: PM 23395
CASE 69 Niemann-Pick Disease Type B Presenting with Massive Splenohepatomegaly and Hypertensive Crisis in a 12-year-old Child: PM 27096
CASE 70 Recurrent Bilateral Multicystic Dysplastic Kidneys, Consistent with Hereditary Renal Adysplasia: PM 20505
CASE 71 Symmetrically Enlarged, Solid Dysplastic Kidneys with Intrauterine Growth Retardation: PM 24340
CASE 72 Multicystic Dysplastic Kidneys with Dilated Ureters and Hypertrophied Urinary Bladder Leading to Obstructed Labor and Uterine Rupture: PM 26207
CASE 73-74 Renal Hypodysplasia: PM 19521, PM 25711
CASE 75 Bilateral Renal Agenesis: PM 24019
CASE 76-80 Unilateral Renal Developmental Malformations: PM 22428, PM 22393, PM 26428, PM 26291, PM 26824
CASE 81 Segmental Renal Dysplasia with Duplex Kidney and Ureterocele: PM 19965
CASE 82-83 Posterior Urethral Valve Leading to Congenital Hydroureteronephrosis and Hypertrophied Urinary Bladder: PM 18485, PM 26118
CASE 84 Neonate with Bilateral Simple Renal Hypoplasia, Lung Hypoplasia and Hydrocephalus: PM 27245
CASE 85 Bilateral Simple Renal Hypoplasia, Cystic Periventricular Leukomalacia with Hydrocephalus ex vacuo in Surviving Twin, after Death of Monochorionic Co-twin: PM 25677
CASE 86 Segmental Hypoplasia (Ask-Upmark Kidney): S-14525/2008
CASE 87 A Classical Case of Autosomal Recessive Polycystic Kidney Disease: PM 22879
CASE 88 Autosomal Dominant Polycystic Kidney Disease with Cyst Infection: PM 22828
CASE 89 Co-existing Glomerulocystic Kidney Disease and Renal Tubular Dysgenesis with Late Onset Oligohydramnios and Renal Failure at D2 of Life: PM 28154
CASE 90 Glomerulocystic Kidney Associated with Posterior Urethral Valve—A Rare Association: PM 28255
CASE 91-92 Meckel-Gruber Syndrome: PM 20070, PM 26190
CASE 93-94 Prune Belly Syndrome Leading to a Markedly Distended Urinary Bladder and Hydroureteronephrosis: PM 23424, PM 25509
CASE 95 Sirenomelia with Bilateral Renal Agenesis and Multiple Other Malformations: PM 27025
CASE 96 Coexistence of Duarte 2 Variant of Galactosemia with Niemann-Pick Disease Type B, in an Infant: PM 23108
CASE 97 A Classical Case of Galactosemia: PM 23869
CASE 98 Galactosemia, Double Heterozygous for N314D and Q188R Mutations, with Micronodular Cirrhosis and Absence of Steatosis: PM 25342
CASE 99 A Case of Galactosemia, Double Heterozygous for Q188R and E308K Mutations with Early Neonatal Acute Liver Failure: PM 25552
CASE 100 Neonate with Hemolytic Disease of Newborn (Due to Rh Isoimmunization—for both Rh-D Antigen and Rh-C Antigen), Conjugated Hyperbilirubinemia, and Associated Nonsyndromic Paucity of Intrahepatic Bile Ducts: PM 27937
CASE 101 Indian Childhood Cirrhosis: PM 24527